Left: Confocal microscopy localizes PfAnkDHHC (palmitoyl transferase) to Golgi. 3D7 schizonts were labeled with (A) rat anti-PfAnkDHHC, and (B) rabbit anti-ERD2, a known Golgi marker. (C) Merged image of the two stains shows extensive co-localization. (D) Corresponding DIC image. All images 630x.

Right: Proposed model of topology of PfAnkDHHC in the Golgi membrane. The DHHC domain is exposed to the cytosol to serve as a palmitoyl transferase to cytosoloic proteins or transmembrane proteins with cysteines.

Seydel KB, Gaur D, Aravind L, Subramanian G, Miller LH. Plasmodium falciparum: characterization of a late asexual stage golgi protein containing both ankyrin and DHHC domains. Exp Parasitol. 2005 110:389-93. Copyright Elsevier 2010.

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