Upper panel: Co-localization of the group A protein PFD1110w (anti-PFD1110w, red) with the group B alveolin PFE1285w (PFE1285w-GFP, green) emphasizes the differential nature of the two structures in the nascent IMC and their spatial relation during the ongoing schizogony (T1-3). Nuclei stained with DAPI. Scale bar 2 μm.

Lower panel: A double transgenic parasite line was generated expressing a different combination of proteins, MAL13P1.130-GFP (group A) and PF10_0039-mCherry. The dynamic distribution of these two members confirmed the spatial distinction but intimate proximity of the group A and group B defined IMC sub-compartments during the early phase of IMC biogenesis.

Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielman T, Parkinson J, Gilberger TW. Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite. Mol Biol Evol. 2012 29(9):2113-32