PF3D7_0503400 actin-depolymerizing factor 1

Expression and localization of actin-depolymerizing factor 1 (PfADF1) and actine 1 (PfAct1) in P. falciparum. IFA of mature P. falciparum schizont stages labeled with PfAct1, PfADF1, and PfRON4 antisera. r, rabbit; m, mouse. (Scale bars, 2 μm.) Immunofluorescence assays (IFA) of schizont stages (before merozoite release) demonstrated broad labeling across the parasite cytosol with the exception of the nucleus (marked by DAPI. This distribution was consistent with that of PfAct1.

Wong W, Skau CT, Marapana DS, Hanssen E, Taylor NL, Riglar DT, Zuccala ES, Angrisano F, Lewis H, Catimel B, Clarke OB, Kershaw NJ, Perugini MA, Kovar DR, Gulbis JM, Baum J. Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1. Proc Natl Acad Sci U S A. 2011 108:9869-74.

Other associated proteins

PFID Formal Annotation
PF3D7_1116000 rhoptry neck protein 4
PF3D7_1246200 actin I