PF3D7_0903200 ras-related protein RAB7

Association between PfRab7 and PfPKA-C-HA in vivo is shown at a single stack of image acquisition. The distribution of PfRab7 (red) is revealed with a specific anti-peptide PfRab7 antibody and the distribution of PfPKA-C-HA (green) is revealed with anti-HA antibodies. The association between PfRab7 and PfPKA-C-HA is shown in white. The level of association between Rab7 and PfPKA-C-HA increases as the parasite develops into a multi-nucleated schizont (nuclei shown stained in blue with DAPI). One can observe a subset of PfRab7+ vesicles associated with a subset of PfPKA-C-HA+ structures. The ability of PfRab7 to bind PfPKA-C suggests that it acts somewhat like a PKA-anchor proteins (AKAP), recruiting PKA to early and late endosomes.

Rached FB, Ndjembo-Ezougou C, Chandran S, Talabani H, Yera H, Dandavate V, Bourdoncle P, Meissner M, Tatu U, Langsley G. Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites. Biol Cell. 2012 104(1):34-47.

Other associated proteins

PFID Formal Annotation
PF3D7_0934800 cAMP-dependent protein kinase catalytic subunit