Expression and cellular localization of MSP-I during bloodstage development. Sections of bloodstage forms of the parasite were labelled with monospecific MSP-1I serum followed by protein A gold labelling and silver enhancement. Panel 1, young trophozoite; panel 2, mature trophozoite; panel 3, young schizont; panel 4, mature schizont; panel 5, a typical contact zone of the parasite with the red blood cell membrane at higher magnification. Note the increase in MSP-l synthesis during development and the localization of MSP-l on the outer parasitophorous membrane (bars indicate 1 mm).

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