PF3D7_1220900 heterochromatin protein 1

PfHP1 localizes to discrete regions at the nuclear periphery. Upper panel: PfHP1-GFP localization in unfixed 3D7/HP1-GFP parasites. T, trophozoites. S, schizonts. Lower panel: Localization of PfHP1-GFP by electron microsopy. Antibodies specific to GFP detect PfHP1-GFP at the nuclear periphery, reminiscent of the pattern seen by fluorescence microscopy (N, nucleus; C, cytoplasm). Schematic map of the transfection constructs is shown above the upper panel.

Flueck C, Bartfai R, Volz J, Niederwieser I, Salcedo-Amaya AM, Alako BT, Ehlgen F, Ralph SA, Cowman AF, Bozdech Z, Stunnenberg HG, Voss TS. Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog. 2009 Sep;5(9):e1000569.