PF3D7_1323500 PEXEL protease plasmepsin V

Localization studies of UBA (E1) and UBC (E2). (A,B) IFA experiments, using different parasite stages, show that PfUBA1 and PfUBC localize mainly to the cytosol. (C) When co-immunostained with plasmepsin V (PMV), a Plasmodium ER membrane protein marker, there was noticeable overlap between the two proteins, suggesting UBA1 recruitment to the ER as well. Both UBC and UBA1 are mainly dispersed throughout the cytoplasm with small aggregations scattered throughout the parasite. UBA1 was co-immuno-stained with PMV, an ER membrane marker, showing noticeable overlap between the two proteins.

Chung DW, Ponts N, Prudhomme J, Rodrigues EM, Le Roch KG. Characterization of the Ubiquitylating Components of the Human Malaria Parasite's Protein Degradation Pathway. PLoS One. 2012;7(8):e43477.

Other associated proteins

PFID Formal Annotation
PF3D7_0208500 acyl carrier protein
PF3D7_1203900 ubiquitin-conjugating enzyme E2
PF3D7_1225800 ubiquitin-activating enzyme E1