DNA fragmentation in P. falciparum parasites as assessed by TUNEL staining. Fluorescent microscopic images of TUNEL-positive parasites (TdT red staining) in treated cultures as compared with controls. The parasite nuclei were stained with DAPI (blue) and parasites were visualized by fluorescence microscope. Dl is a synthetic peptide that binds PfClpQ, thereby revealing it location. ClpQ protease is located in the matrix of the mitochondrion.

Rathore S, Jain S, Sinha D, Gupta M, Asad M, Srivastava A, Narayanan MS, Ramasamy G, Chauhan VS, Gupta D, Mohmmed A. Disruption of a mitochondrial protease machinery in Plasmodium falciparum is an intrinsic signal for parasite cell death. Cell Death Dis. 2011 24;2:e231.