PF3D7_1246200 actin I

Right: PfSec13 is associated with γ-tubulin rather than with F-actin. Super resolution IFAs of the PfSec13-GFP (green) expressing parasites that were co-stained with F-actin (red) using rabbit α- Act239-253. Nuclei were stained with DAPI (blue). The size bar represents 1μm. (B), IFAs showing co-localization of PfSec13–GFP (green) and γ-tubulin (red) during the IDC. later in the IDC PfSec13 remains located at the nuclear periphery while F-actin is spread throughout the entire cell .

Left: PfSec13 is associated with γ-tubulin rather than with F-actin. IFAs showing co-localization of PfSec13–GFP (green) and γ-tubulin (red) during the IDC. PfSec13 is associated with F-actin at the nuclear periphery. The association of PfSec13 with γ-tubulin may indicate a possible role of microtubules in NPCs dynamics.

Dahan-Pasternak N, Nasereddin A, Kolevzon N, Pe'er M, Wong W, Shinder V, Turnbull L, Whitchurch CB, Elbaum M, Gilberger TW, Yavin E, Baum J, Dzikowski R. PfSec13 is an unusual chromatin associated nucleoporin of Plasmodium falciparum, which is essential for parasite proliferation in human erythrocytes. J Cell Sci. 2013 126(Pt 14):3055-69

Other associated proteins

PFID Formal Annotation
PF3D7_0803700 tubulin gamma chain
PF3D7_1230700 protein transport protein SEC13
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