PF3D7_1229100 multidrug resistance-associated protein 2, MRP2

Immunofluorescence images of PfMRP2 localization labelled with Alexa488 during the development from ring to trophozoite and schizont stages in the wild-type clone 11C parasite. Nucleus was stained with DAPI (4′,6′-diamidino-2-phenylindole). The bottom panel shows dual labelling of the parasite at early schizont stage with anti-PfMRP2 (Alexa488) antibody and digestive vacuole-specific PfCRT antibody (Alexa594). In all asexual blood stages of 11C/wt, the PfMRP2 IFAsignal exhibited a punctate pattern suggesting its association with membranous vesicles within the parasite cytoplasm. In the ring stage, PfMRP2-associated compartments concentrated to the periphery of the parasite, while in trophozoite and schizont stages these were more dispersed throughout the cytoplasm. The signal also appeared discrete and punctuated around individual merozoites in the mature schizonts just prior to rupture.

Mok S, Liong KY, Lim EH, Huang X, Zhu L, Preiser PR, Bozdech Z. Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs. Mol Microbiol. 2014 91(5):918-34.

Other associated proteins

PFID Formal Annotation
PF3D7_0709000 chloroquine resistance transporter