PF3D7_1021800 schizont egress antigen-1

Immunolocalization of PfSEA-1. (A) Infected RBCs were probed with mouse anti–PfSEA-1 (green) and rabbit anti–MSP-1 (red) and counterstained with 4',6'-diamidino-2-phenylindole (DAPI) to label parasite nuclei. PfSEA-1 is detected only in schizont-infected RBCs. Scale bar for free merozoite images, 2 mm. Scale bar for remaining images, 10 mm. Anti–PfSEA-1 did not bind to free merozoites, rings, or late trophozoite–stage parasites, but did specifically recognize an antigen expressed by late schizont–infected RBCs.

Raj DK, Nixon CP, Nixon CE, Dvorin JD, DiPetrillo CG, Pond-Tor S, Wu HW, Jolly G, Pischel L, Lu A, Michelow IC, Cheng L, Conteh S, McDonald EA, Absalon S, Holte SE, Friedman JF, Fried M, Duffy PE, Kurtis JD. Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection. Science. 2014 344(6186):871-7.

Other associated proteins

PFID Formal Annotation
PF3D7_0930300 merozoite surface protein 1