PF3D7_0202000 knob-associated histidine-rich protein

PTEX150 knockdown blocks protein export in P. falciparum. a–e, IFAs (right) and graphs (left) showing a decrease in the export of RESA (a) and KAHRP (b) and of SBP1 (c) and Hyp8 (d) (Maurer’s clefts, MCs) cells for each antibody or GlcN concentration) but similar levels of MSP8 (e) after treatment with GlcN. Scale bars, 5 mm. A strong blockage in export was seen at both 2.5mM and 0.15mM glucosamine in PTEX150-HAglmS parasites (a, b, c and d). No effect on either MSP8 expression or localization to the parasite membrane was observed (e).

Elsworth B, Matthews K, Nie CQ, Kalanon M, Charnaud SC, Sanders PR, Chisholm SA, Counihan NA, Shaw PJ, Pino P, Chan JA, Azevedo MF, Rogerson SJ, Beeson JG, Crabb BS, Gilson PR, de Koning-Ward TF. PTEX is an essential nexus for protein export in malaria parasites. Nature. 2014 Jul 16. [Epub ahead of print] PMID: 25043043

Other associated proteins

PFID Formal Annotation
PF3D7_0102200 ring-infected erythrocyte surface antigen
PF3D7_0501300 skeleton-binding protein 1
PF3D7_0502400 ring-stage membrane protein 1 merozoite surface protein 8
PF3D7_1300800 erythrocyte membrane protein 1 (pfemp1), pseudogene