PF3D7_1116400 guanine nucleotide-exchange factor SEC12

Characterization of PfSec12. Live cell imaging of parasites expressing GFP-PfSec12 from the endogenous pfsec12 5′ UTR. Nuclei were stained with Hoechst 33342. GFP-PfSec12 is distributed in a perinuclear pattern with additional reticular protrusions characteristic of the parasite ER. Parasites at the ring, trophozoite and schizont stages are shown in the top, middle and bottom rows respectively. Note that the trophozoites (labelled P) were in a doubly infected erythrocyte. Bar = 5 μm.

Lee MC, Moura PA, Miller EA, Fidock DA. Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif. Mol Microbiol. 2008 68(6):1535-46. PMID:

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