PF3D7_0102200 ring-infected erythrocyte surface antigen

A. Domain architecture of PF3D7 0102200 (RESA), not to scale. PRESAN, domain boundaries defined according to Pfam ID: PF09687; DnaJ domain as defined byPfam ID: PF14308; SBD, spectrin-binding domain. (B–E) Domain architecture and localisation of HT:RESA:GFP reporter constructs. REX31–61, N-terminal sequence of REX3,including its HT motif, which is sufficient to drive protein export. Residue numbers, below each diagram, refer to position within full-length RESA. The left- and right-hand images show GFP localisation and a phase contrast image, respectively. Scale bar, 2 mm. The identity of each parasite line is indicated above the respective images. the extended PRESAN domain of RESA, a known cytoskeleton-associated protein, efficiently targets to the erythrocyte periphery.

Tarr SJ, Moon RW, Hardege I, Osborne AR. A conserved domain targets exported PHISTb family proteins to the periphery of Plasmodium infected erythrocytes. Mol Biochem Parasitol. 2014 196(1):29-40