Peripherally associated proteins MSP3, MSP7, SERA4, and SERA5 are shed during invasion. Invading merozoites were labeled with PfRON4 as a marker of the tight junction (green) and colabeled with antibodies directed against MSP3 (A), MSP7 (B), SERA4 (C), or SERA5 (D). All proteins were shed at the point of tight junction, with antibody reactivity to the merozoite surface being observed only on the proportion of the merozoite external to the RBC. All primary antibodies were used at a 1:100 serum dilution, and secondary antibodies were used at a 1:500 dilution.
Boyle MJ, Langer C, Chan JA, Hodder AN, Coppel RL, Anders RF, Beeson JG. Sequential processing of merozoite surface proteins during and after erythrocyte invasion by Plasmodium falciparum. Infect Immun. 2014 82(3):924-36.
Other associated proteins
|PF3D7_0207600||serine repeat antigen 5|
|PF3D7_0207700||serine repeat antigen 4|
|PF3D7_1035400||merozoite surface protein 3|