PF3D7_0423500 glideosome associated protein with multiple membrane spans 2

Over-expression and localization of PfDHHC3 and PFDHHC9 (PF11_0167) in late stage parasites. C. Expression of PfDHHC3-mCherry. C. Expression of PfDHHC3-mCherry. C2. Microscopic analysis located this GFP-fusion protein in the periphery of the nascent merozoites. C3. Co-localization with the IMC marker GAPM2 (anti-GAPM2, green) in fixed cells shows differential localization of PfDHHC2-mCherry with the IMC localization in early stages (T1) and colocalization in nascent merozoites (T3) consistent with plasma membrane association. Scale bar, 1 μm. D.

Expression of PfDHHC9-mCherry. D2. Microscopy localized this fusion protein mainly in apical structures in the parasite. D3. Co-localization with the IMC marker GAPM2 (anti-GAPM2, green) in fixed cells shows differential localization of PfDHHC9 with the IMC (T3). Scale bar, 1 μm.

Wetzel J, Herrmann S, Swapna LS, Prusty D, Peter AT, Kono M, Saini S, Nellimarla S, Wong TW, Wilcke L, Ramsay O, Cabrera A, Biller L, Heincke D, Mossman K, Spielmann T, Ungermann C, Parkinson J, Gilberger TW. The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite. J Biol Chem. 2014 Nov 25.

Other associated proteins

PFID Formal Annotation
PF3D7_1115900 palmitoyltransferase DHHC9
PF3D7_1121000 palmitoyltransferase DHHC3
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