PF3D7_0303400 palmitoyltransferase

PfDHHC1 is an IMC localized palmitoyl acyltransferase. E. PfDHHC1-GFP was localized in unfixed late stage parasites showing characteristic IMC dynamics during schizogony (T1-T3). Nuclei stained with DAPI (blue). Enlargement of selected areas are marked with a white square and referred as zoom. Scale bar, 1 μm. F. Co-localization of PfDHHC1-GFP and PfISP3mCherry. PfISP3mCherry was episomally co-expressed and shows identical spatial distribution compared with PfDHHC1-GFP. G. PfDHHC1-GFP distribution within the nascent IMC during gametocytog-enesis (stage IV and V). These symmetric sutures of the IMC are expanding with ongoing growth of the IMC vesicles and maturation of the gametocytes (stage III and IV). Scale bars, 1 μm.

Wetzel J, Herrmann S, Swapna LS, Prusty D, Peter AT, Kono M, Saini S, Nellimarla S, Wong TW, Wilcke L, Ramsay O, Cabrera A, Biller L, Heincke D, Mossman K, Spielmann T, Ungermann C, Parkinson J, Gilberger TW. The role of palmitoylation for protein recruitment to the inner membrane complex of the malaria parasite. J Biol Chem. 2014 Nov 25. PMID:

Other associated proteins

PFID Formal Annotation
PF3D7_1460600 inner membrane complex sub-compartment protein 3