PF3D7_0424100 reticulocyte binding protein homologue 5

Left: Immunofluorescence microscopy detected CyRPA to colocalize with micronemal proteins (EBA-175, PfRipr). (Scale bar, 2 μm.)

Right: PfRH5/PfRipr/CyRPA complex is GPI-anchored to the merozoite surface. (A) 3D reconstruction of IFA z-stacks during merozoite invasion, coimmunostained with MSP-1 detected PfRH5, PfRipr, and CyRPA at the apical end of the merozoite surface. In the 3D images, the γ settings were altered for visual representation only,

Reddy KS, Amlabu E, Pandey AK, Mitra P, Chauhan VS, Gaur D. Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasion. Proc Natl Acad Sci U S A. 2015 Jan 12.

Other associated proteins

PFID Formal Annotation
PF3D7_0323400 Rh5 interacting protein
PF3D7_0423800 RH5-Ripr membrane anchoring protein cysteine-rich protective antigen
PF3D7_0731500 erythrocyte binding antigen-175