Apicoplasts distribute normally into the progeny of antibiotic-treated parasites but are abnormal in the following cycle. ACPl-GFP 3D7 strain transgenic parasites were treated with antibiotics at twice the IC50 at 96 h (100 nM azithromycin [AZ], 6 mM ciprofloxacin [CIP], 25 nM clindamycin [CLN], and 1 mM doxycycline [DOX]), and representative live parasites were imaged by fluorescence microscopy. GFP-labeled apicoplasts are green; Hoechst-stained nuclei are blue.

Dahl EL, Rosenthal PJ. Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother. 2007 51(10):3485-90.