PF3D7_1022500 citrate synthase, mitochondrial, putative

Clindamycin and tetracycline treatment results in “delayed-death” and significant defects in the apicoplast and mitochondrial morphology. Scanning confocal microscopy images of live P. falciparum expressing ACPLRFP (apicoplast - red) and CSLYFP (mitochondria - green) and stained with Hoescht 33342 (DNA—blue) after 48 h without drug treatment. (E) Images taken after 48 h treatment with 100nM clindamycin. (F) Images taken after 48 h treatment with 10mM tetracycline. (G) Images of clindamycin treated parasite after 72 h. (H) Images of tetracycline treated parasite after 72 h. Arrow indicates spherical body which may be the apicoplast. (I) Images of untreated parasite after 72 h.

Goodman CD, Su V, McFadden GI. The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 2007 52(2):181-91

Other associated proteins

PFID Formal Annotation
PF3D7_0208500 acyl carrier protein