Localisation of SBP-1 in normal and protein 4.1R-deficient red blood cells. Representative confocal immunofluorescence images of normal (A) and 4.1R-deficient (C) RBCs immunolabelled for Maurer's clefts (SBP1; green) and the RBCmembrane skeleton (Glycophorin A, GpA; red). This data strongly supports that the interaction between SBP1-C and protein 4.1R plays a significant role in localising Maurer's clefts to their final destination in the PRBC, tethered to the RBC membrane skeleton.
Kats LM, Proellocks NI, Buckingham DW, Blanc L, Hale J, Guo X, Pei X, Herrmann S, Hanssen EG, Coppel RL, Mohandas N, An X, Cooke BM. Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells. Biochim Biophys Acta. 2015 Apr 1848(7):1619-1628. PMID: