Functional analysis of the SBP1 C-terminal domain. A. Representative images from immunofluorescence analysis RBCs infected with wild type 3D7 parasites or the three clonal parasite lines for the SBP1–AMA1-C chimeras (clones 1C9, 1D7 and 1G3 expressing chimeric SBP1 comprising the N-terminal domain of SBP1 and the C-terminal domain of AMA1 (SBP1–AMA1-C). Green represents SBP1 and red is spectrin. Distribution of the chimeras in PRBCs was not significantly different to that found in wild type, parental 3D7 parasites.
Kats LM, Proellocks NI, Buckingham DW, Blanc L, Hale J, Guo X, Pei X, Herrmann S, Hanssen EG, Coppel RL, Mohandas N, An X, Cooke BM. Interactions between Plasmodium falciparum skeleton-binding protein 1 and the membrane skeleton of malaria-infected red blood cells. Biochim Biophys Acta. 2015 Apr 1848(7):1619-1628.