PF3D7_1246100 delta-aminolevulinic acid synthetase

Co-localization of ALAS with MitoTracker dye and Hsp60 in P. falciparum. Top row : (a) bright ®eld (the contour of the infected cell is indicated since it is not clearly visible) ; (b) Hoechst stain ; (c) MitoTracker fluorescence in parasite ; (d) ALAS immuno¯uorescence with PfALAS antibody and FITC-conjugated secondary antibody ; (e) co-localization of (c) and (d). Bottom row : (a) bright field ; (b) Hoescht stain ; (c) Hsp60 immunofuorescence with Hsp60 antibody in rabbits and tetramethylrhodamine b-isothiocyanate (TRITC)-conjugated anti-rabbit antibody in goat ; (d) ALAS immuno-fluorescence with ALAS antibody in mice and FITC-conjugated anti-mouse antibody in goat ; (e) c-localization of (c) and (d).

Varadharajan S, Dhanasekaran S, Bonday ZQ, Rangarajan PN, Padmanaban G. Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparum. Biochem J. 2002 Oct 15;367(Pt 2):321-7. PubMed

Other associated proteins

PFID Formal Annotation
PF3D7_1015600 heat shock protein 60