PF3D7_0217500 Calcium-dependent protein kinases; CDPK1

Inhibition of PfCDPK1 has no effect on asexual parasite growth. Immunofluorescence using anti-HA and anti-CDPK1 antibodies confirms that CDPK1 T145G-HA (a gatekeeper mutant) localizes correctly to the plasma membrane of parasites. Scale bar is 1 μm.

Ansell KH, Jones HM, Whalley D, Hearn A, Taylor DL, Patin EC, Chapman TM, Osborne SA, Wallace C, Birchall K, Large J, Bouloc N, Smiljanic-Hurley E, Clough B, Moon RW, Green JL, Holder AA. Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1. Antimicrob Agents Chemother. 2014 58(10):6032-43.