PF3D7_0202000 knob-associated histidine-rich protein

Correct PEXEL positioning is essential for export. (a) KAHRP1–96 and KAHRPD38–48 are exported to the P. falciparum-infected erythrocyte but KAHRPD38–53 and KAHRPD38–53 RLQ4A accumulate in the PV and are not exported. KAHRP16Ala, KAHRP10Ala and KAHRP5Ala are exported to the red blood cell. Scale bar, 5 mm.

Boddey JA, O'Neill MT, Lopaticki S, Carvalho TG, Hodder AN, Nebl T, Wawra S, van West P, Ebrahimzadeh Z, Richard D, Flemming S, Spielmann T, Przyborski J, Babon JJ, Cowman AF. Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding. Nat Commun. 2016 Feb 1;7:10470.