PF3D7_0417200 bifunctional dihydrofolate reductase-thymidylate synthase

Communication between Parasites Results in the DNA-Dependent Transfer of Drug Resistance and Fluorescence.. Fluorescence microscopy of live 3D7idhfrmCh (mCherry) and CS2eBsdGFP (GFP) cocultured. Top, 3D7idhfrmCh expression of mCherry (red) in nucleus. Second panel, CS2eBsdGFP expression of GFP in cytoplasm. Bottom, examples of CS2eBsdGFP+3D7idhfrmCh cocultures in Bs+WR after 5 days. DAPI-stained images (blue) show the nucleus and final image merged.

Regev-Rudzki N, Wilson DW, Carvalho TG, Sisquella X, Coleman BM, Rug M, Bursac D, Angrisano F, Gee M, Hill AF, Baum J, Cowman AF. Cell-Cell Communication between Malaria-Infected Red Blood Cells via Exosome-like Vesicles. Cell. 2013 May 23;153(5):1120-33.