PF3D7_0501300 skeleton-binding protein 1

Translocation arrested substrates induce a pan export block that slows parasite development. (A) Representative live fluorescence images of the cell line expressing endogenous SBP1 fused to mDHFR-GFP (SBP1-mDHFR-GFPendo) grown with (+WR) and without WR (control). DIC, differential interference contrast. Size bar: 5 μm. (B) IFA of SBP1-mDHFR-GFPendo parasites using α-REX1 and α-KAHRP in parasites treated with (+WR) and without (control) WR. Size bars: 5 μm.

Mesén-Ramírez P, Reinsch F, Blancke Soares A, Bergmann B, Ullrich AK, Tenzer S, Spielmann T. Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity. PLoS Pathog. 2016 May 11;12(5):e1005618.

Other associated proteins

PFID Formal Annotation
PF3D7_0202000 knob-associated histidine-rich protein
PF3D7_0935900 ring-exported protein 1