The hypothetical model of trafficking pathway involved in PfRab5b. N-acylated proteins, such as PfAK2, are recruited to novel compartment(s) adjacent to the ER, and packed into the multivesicular body or an autophagosome-like double membrane structure together with PfRab5b. The multivesicular body fuses with the PPM, and internal vesicles fuses with the PVM. Rab5b is clustered on the TVN. Nuc, nucleus; RBC, red blood cell; PTEX, Plasmodium translocon of exported proteins; PAT, palmitoyltransferase. EVP1 and SBP1 are exported proteins with and without the
Plasmodium export element (PEXEL) signal, respectively .
Ebine K, Hirai M, Sakaguchi M, Yahata K, Kaneko O, Saito-Nakano Y. Plasmodium Rab5b is secreted to the cytoplasmic face of the tubovesicular network in infected red blood cells together with N-acylated adenylate kinase 2. Malar J. 2016 15:323.