PF3D7_0424100 reticulocyte binding protein homologue 5

Subcellular Localization of PfRipr, CyRPA, and PfRh5 in Schizonts and Invading Merozoites

(A) Top panel: Overlay of CyRPA (green) and PfRipr (red) with DAPI and DIC fields. Middle panel, overlay of CyRPA (green) and PfRh5 (red) with DAPI and

DIC fields. Lower panel, overlay of PfRipr (green) and PfRh5 (red) with DAPI and DIC images.

(B) Merozoites were mixed with erythrocytes and CyRPA, PfRipr, and PfRh5 visualized. Top panel, colocalization of CyRPA (green) and PfRipr (red) with DAPI and DIC images. Two merozoites invading a single erythrocyte. Middle panel, overlay of CyRPA (green) and PfRh5 (red) with DAPI and DIC fields with a single merozoite. Lower panel, overlay of PfRipr (green) and PfRh5 (red) with

DAPI and DIC images. White bar indicates 5 mm.

Volz JC, Yap A, Sisquella X, Thompson JK, Lim NT, Whitehead LW, Chen L, Lampe M, Tham WH, Wilson D, Nebl T, Marapana D, Triglia T, Wong W, Rogers KL, Cowman AF. Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes. Cell Host Microbe. 2016 Jun 30 [Epub ahead of print] PMID: 27374406

Other associated proteins

PFID Formal Annotation
PF3D7_0323400 Rh5 interacting protein
PF3D7_0423800 RH5-Ripr membrane anchoring protein cysteine-rich protective antigen
img