BMS-386914 inhibits FCP prenylation and causes mislocalization to the cytosol. Live microscopy of GFP-FCP expressing parasites treated with

10x EC50 BMS-386914 or lonafarnib. The nucleus was stained using Hoechst. In contrast, lonafarnib showed no effect on FCP prenylation or localization even at 10x EC50 concentrations (Figure 5B and 5C). These results show that BMS-386914 inhibits prenylation and proper localization of FCP as part of its antimalarial mechanism-of-action.

Gisselberg JE, Zhang L, Elias JE, Yeh E. The prenylated proteome of Plasmodium falciparum reveals pathogen-specific prenylation activity and drug mechanism-of-action. Mol Cell Proteomics. 2016 Dec 31. pii: mcp.M116.064550.