PF3D7_0202000 knob-associated histidine-rich protein

RhopH proteins are deposited in the PV and exported via PTEX. IFA of 13F10 showing export of RhopH proteins after growth with or without TMP for 48 h. Colocalization with exported HRP2 or SBP1, as indicated. Scale bars, 5 μm. Export of RhopH2 and RhopH3 were both fully blocked in trophozoite-stage parasites grown for 48 h without TMP. Colocalization with HRP2, a parasite protein carrying the canonical PEXEL export signal showed both proteins trapped in the vacuole upon PTEX knockdown. CLAG3 export requires PTEX activity as TMP removal prevented its movement out of the PV (bottom row); colocalization with SBP1, another PTEX substrate.

Ito D, Schureck MA, Desai SA. An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites. Elife. 2017 Feb 21;6.

Other associated proteins

PFID Formal Annotation
PF3D7_0302200 cytoadherence linked asexual protein 3.2
PF3D7_0501300 skeleton-binding protein 1
PF3D7_0905400 high molecular weight rhoptry protein 3
PF3D7_0929400 high molecular weight rhoptry protein 2