PF3D7_1410400 rhoptry-associated protein 1

Trafficking of apical proteins is not affected by RAP1 knockdown IFA of schizont stage parasites showing that trafficking of rhoptry (RAMA, RHOPH3, RON6) and micronemal (AMA1) proteins is not affected when RAP1 or RAP2 expression is depleted from parasites with anhydrotetracycline )Atc(. No apparent difference in the electron density or morphology of the rhoptries was observed (Left panel), suggesting that RAP2 is not essential for rhoptry formation in Plasmodium spp. Moreover, knockdown of either RAP1 or RAP2 expression did not affect parasite maturation and replication, as there was no significant difference observed in merozoite number or schizont formation compared to parasites grown in the absence of ATc (right panel).

Ghosh S, Kennedy K, Sanders P, Matthews K, Ralph SA, Counihan NA, de Koning-Ward TF. The Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth. Cell Microbiol. 2017.

Other associated proteins

PFID Formal Annotation
PF3D7_0831600 cytoadherence linked asexual protein 8
PF3D7_0905400 high molecular weight rhoptry protein 3
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