PF3D7_1457200 thioredoxin 1

The expression of PfTPx-1 (A), Pf1-Cys-Prx (B), and PfTrx-1 (C) proteins in P. falciparum cells during the erythrocytic stage. Parasite cells in panels (A–C) are stained with antiserum specific for each antioxidant protein (Alexa Fluor 568, red) and TO-PRO-3 iodide (blue; nucleolus staining). Letters with arrows are ring stage (R), schizont (S), and late trophozoite (T). Immunofluorescence microscopy of P. falciparum erythrocytic-stage parasites revealed that PfTPx-1 was expressed in the parasite cytoplasm during the ring, trophozoite and schizont stages. PfTPx-1 thus showed constitutive expression through the erythrocytic stage A). In contrast, significant staining of Pf1-Cys-Prx was detected in the trophozoites in the cytoplasm of the parasite. Expression of Pf1-Cys-Prx in late schizonts was weak in comparison to that of PfTPx-1 in parasites of the same stage, and it was not detected in the ring stage. Pf1-Cys-Prx thus showed limited expression during the trophozoite and early schizont stages (B). Significant expression of PfTrx-1 was observed after the trophozoite stage, but expression was weak during the ring stage (C).

Yano K, Komaki-Yasuda K, Kobayashi T, Takemae H, Kita K, Kano S, Kawazu S. Expression of mRNAs and proteins for peroxiredoxins in Plasmodium falciparum erythrocytic stage. Parasitol Int. 2005 Mar;54(1):35-41.

Other associated proteins

PFID Formal Annotation
PF3D7_0802200 1-cys peroxiredoxin
PF3D7_1438900 thioredoxin peroxidase 1