PfSAC1-3HA is found in the endoplasmic reticulum and enriched at or close to the Golgi apparatus. (a) Colocalisation analysis between PfSAC1-3HA and the endoplasmic reticulum marker Bip. Some overlap is observed between the two signals throughout the blood stages though it decreases in schizonts. (b) Colocalisation analysis between PfSAC1-3HA and the Golgi apparatus marker ERD2. PfSAC1-3HA shows extensive overlap with ERD2 in rings (i) and trophozoites (ii) but this decreases in schizonts (iii). PfSAC1-3HA overlaps with some parts of the ER in rings, trophozoites and schizonts, sometimes in close apposition/overlapping to foci of the ER marker. BipPfSAC1-3HA signal overlaps extensively with the Golgi apparatus signal. When the parasite goes from the trophozoite (3bii) to the schizont stage (3biii), the overlap between the two signals seems to decrease.
Thériault C, Richard D. Characterization of a putative Plasmodium falciparum SAC1 phosphoinositide-phosphatase homologue potentially required for survival during the asexual erythrocytic stages. Sci Rep. 2017 Oct 5;7(1):12710.
Other associated proteins
|PF3D7_1353600||ER lumen protein retaining receptor|
|PF3D7_1354200||phosphoinositide phosphatase sac1|