PF3D7_1105000 histone H4

The residue K31 on the lateral surface of histone H4 is a novel PTM. Immunofluorescence analysis of H4K31ac (in red) in both human foreskin fibroblast cells and parasites nuclei. DNA (top) was stained with Hoechst. Scale bar, 10 mm. H4K31ac was found to be exclusively and uniformly distributed within the nuclei of both parasite and human cells.

Sindikubwabo F, Ding S, Hussain T, Ortet P, Barakat M, Baumgarten S, Cannella D, Palencia A, Bougdour A, Belmudes L, Couté Y, Tardieux I, Botté CY, Scherf A, Hakimi MA. Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites. Elife. 2017 Nov 4;6. pii: e29391.