Phosphatidylinositol 4-monophosphate is found at the Golgi apparatus throughout the Plasmodium falciparum erythrocytic cycle. (A) The PHFAPP-3HA sensor
colocalises extensively with the Golgi marker Endoplasmic reticulum Retention Defective protein 2 (ERD2) in rings (a), trophozoites (Troph) (b), schizonts (Schiz) (c) and free merozoites (Mero) (d). Colocalisation experiments revealed that PHFAPP-3HA overlapped extensively with Golgi ERD2 throughout the erythrocytic cycle. IFAs performed with antibodies to Apical membrane antigen 1 (AMA1) and Erythrocyte binding antigen 175 (EBA175), markers of two different micronemal populations, failed to show any strong overlap with PHFAPP-3HA (Ca,b)
Ebrahimzadeh Z, Mukherjee A, Richard D. A map of the subcellular distribution of phosphoinositides in the erythrocytic cycle of the malaria parasite Plasmodium falciparum. Int J Parasitol. 2017 Nov 15. pii: S0020-7519(17)30322-3.
Other associated proteins
|PF3D7_0707300||rhoptry-associated membrane antigen|
|PF3D7_0731500||erythrocyte binding antigen-175|
|PF3D7_1116000||rhoptry neck protein 4|
|PF3D7_1353600||ER lumen protein retaining receptor|