PF3D7_0905400 high molecular weight rhoptry protein 3

PfRhopH3 protein is a ligand for Cyclophilin B protein during merozoite binding. a Binding of Cyclophilin B on Merozoite surface. Binding shows binding of CypB on merozoite surface without treatment with any antibody. anti-Rap2b + CypB and anti-RhopH3-C + CypB show binding after treatment with anti-Rap2b and anti-RhopH3 antibody respectively. Intensity for each merozoite is mentioned at the top. Anti-RhopH3-C antibody interferes with binding of CypB on merozoites, signifying that PfRhopH3 is a ligand for host Cyclophilin B. Scale bar = 5 μm.

Prakash P, Zeeshan M, Saini E, Muneer A, Khurana S, Kumar Chourasia B, Deshmukh A, Kaur I, Dabral S, Singh N, Anam Z, Chaurasiya A, Kaushik S, Dahiya P, Kalamuddin M, Kumar Thakur J, Mohmmed A, Ranganathan A, Malhotra P. Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum. Nat Commun. 2017 8(1):1548.

Other associated proteins

PFID Formal Annotation
PF3D7_0501600 rhoptry-associated protein 2
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