Subcellular co-localization of PK4 (green) and BiP (red) as revealed by immunofluorescence in erythrocytic stages of P. berghei. DAPI (blue) was used as a co-stain to show the parasite nuclei. Scale bar, 10 mm. PK4 localizes to the parasite endoplasmic reticulum (ER) in a complex with the ER-resident chaperone BiP.
Zhang M, Gallego-Delgado J, Fernandez-Arias C, Waters NC, Rodriguez A, Tsuji M, Wek RC, Nussenzweig V, Sullivan WJ Jr. Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency. Cell Host Microbe. 2017 22(6):766-776.e4. PMID: 29241041.
Other associated proteins