Effect of K13 mutation and/or drug-exposure on PfEMP1 expression and export. c. 4 nM DHA potently inhibits PfEMP1 export (green; detected by ATS-antibodies in IFA) to the red cell in artemisinin sensitive PfNF54K13WT but not resistant PfNF54K13C580Y. Right panel. Quantitative analyses
of sensitivity of PfEMP1 export (green) to DHA in the artemisinin sensitive clinical strain ANL-1 but not its resistant clinical counterpart ANL-2 (C580Y). P, parasite; R red cell; Scale bars, 5 μm.
Bhattacharjee S, Coppens I, Mbengue A, Suresh N, Ghorbal M, Slouka Z, Safeukui I, Tang HY, Speicher DW, Stahelin RV, Mohandas N, Haldar K. Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance. Blood. 2018 Jan 23. pii: blood-2017-11-814665. [Epub ahead of print] PMID: 29363540.
Other associated proteins