Orc2 gets trafficked to the nucleus through the classical secretory pathway IFA of PfOrc2C with Plasmepsin V (an ER marker) showed co-localization with PfOrc2C post BFA treatment. PfOrc2C colocalized with PMV after BFA treatment whereas it showed punctate foci different from that of PMV in untreated parasites. These results indeed suggest that PfOrc2 gets accumulated within the ER after BFA treatment and that PfOrc2C is continuously being trafficked from the ER to the nucleus.

Sharma R, Sharma B, Gupta A, Dhar SK. Identification of a novel trafficking pathway exporting a replication protein to nucleus via classical secretory pathway in Plasmodium falciparum. Biochim Biophys Acta. 2018 Mar 7. [Epub ahead of print]