Knocking down PfSortilin abrogates trafficking to the apical organelles and prevents rhoptry formation. (A) IFA showing that the rhoptry bulb protein RAP1 traffics to the PV or remains trapped in the ER like the rhoptry neck protein RON4 and the micronemal proteins AMA1 and EBA175.

Hallée S, Counihan NA, Matthews K, de Koning-Ward TF, Richard D. The malaria parasite Plasmodium falciparum Sortilin is essential for merozoite formation and apical complex biogenesis. Cell Microbiol. 2018 Mar 26:e12844 [Epub ahead of print]