PF3D7_1133400 apical membrane antigen 1

Knocking down PfSortilin abrogates trafficking to the apical organelles and prevents rhoptry formation. (A) IFA showing that the rhoptry bulb protein RAP1 traffics to the PV or remains trapped in the ER like the rhoptry neck protein RON4 and the micronemal proteins AMA1 and EBA175.

Hallée S, Counihan NA, Matthews K, de Koning-Ward TF, Richard D. The malaria parasite Plasmodium falciparum Sortilin is essential for merozoite formation and apical complex biogenesis. Cell Microbiol. 2018 Mar 26:e12844 [Epub ahead of print]

Other associated proteins

PFID Formal Annotation
PF3D7_0731500 erythrocyte binding antigen-175
PF3D7_1116000 rhoptry neck protein 4
PF3D7_1410400 rhoptry-associated protein 1
PF3D7_1451800 sortilin