PfSERA5 and PfCDPK1 co-localize in parasitophorous vacuole (PV) of P. falciparum schizonts. Confocal microscopy analysis of P. falciparum schizonts demonstrates that PfSERA5 and PfCDPK1 co-localize in the PV. PfCDPK1 is localized to the parasitophorous vacuole (PV) of P. falciparum-infected erythrocytes similar to the localization observed for PfSERA5. Colocalization studies using immunofluorescence assays confirmed co-localization of PfSERA5 and PfCDPK1 in the PV of schizonts.

Iyer GR, Singh S, Kaur I, Agarwal S, Siddiqui MA, Bansal A, Kumar G, Saini E, Paul G, Mohmmed A, Chitnis CE, Malhotra P. Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen-5 triggers merozoite egress. J Biol Chem. 2018 [ahead of print]