GAP45 is required for invasion but not for microneme discharge. IFA showing relocalization of microneme protein AMA1 to the merozoite periphery in both mock-treated and ΔGAP45 parasites. Bar, 5 mm. IFA analysis of highly mature, segmented schizonts showed that translocation of AMA1 to the surface of ΔGAP45 parasites occurred as normal, indicating that microneme secretion is unaffected by the absence of GAP45.
Perrin AJ, Collins CR, Russell MRG, Collinson LM, Baker DA, Blackman MJ. The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress. MBio. 2018 Jul 3;9(4). pii: e00905-18.
Other associated proteins
|PF3D7_1222700||glideosome-associated protein 45|