PF3D7_1323500 PEXEL protease plasmepsin V

Identifying PfSPC25 as an interacting partner of PMV. Immunofluorescence of 3D7 parasites at the ring, trophozoite and schizont stages using anti-PfSPC25 (green) and anti-PMV (red) antibodies. Brightfield (BF) images are also shown. The parasite nuclei are shown stained with DAPI (blue). Examples of apparent colocalization between PfSPC25 and PMV (indicated with asterisks) have been magnified and are shown in the insets. N = 3 biologically independent samples used. Scale bar, 5 μm.

Marapana DS, Dagley LF, Sandow JJ, Nebl T, Triglia T, Pasternak M, Dickerman BK, Crabb BS, Gilson PR, Webb AI, Boddey JA, Cowman AF. Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte. Nat Microbiol. 2018 Aug 20. [Epub ahead of print]

Other associated proteins

PFID Formal Annotation
PF3D7_1345900 kinetochore protein SPC25, putative