PF3D7_1222600 AP2 domain transcription factor AP-G

PfAP2-G expression dynamics. a, IFA analysis of PfAP2-G–HA and the early gametocyte marker Pfs16 in E5-HA cultures. Images are representative of six independent experiments. Scale bars, 2 μ m. We observed Pfs16 signal in some parasites without detectable pigment (sexual ring), consistent with the observation that expression of this marker starts before the previously reported 30–40 h.p.i. These results suggest that single-nucleated, hemozoin-containing parasites that are positive for PfAP2-G but negative for Pfs16 are sexually committed trophozoites rather than very early stage I gametocytes that do not express Pfs16 at detectable levels yet.

Bancells C, Llorà-Batlle O, Poran A, Nötzel C, Rovira-Graells N, Elemento O, Kafsack BFC, Cortés A. Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum. Nat Microbiol. 2018 PMID: 30478286.

Other associated proteins

PFID Formal Annotation
PF3D7_0406200 parasitophorous vacuole membrane protein s16; sexual stage-specific protein s16