Localization of PfGARP in P. falciparum-infected human erythrocytes. (A) PfGARP was detected in trophozoite and schizont stages of parasite infection but not in the ring stage. PfGARP appears a punctate pattern particularly enriched at the erythrocyte periphery during the schizont stage of parasite development. White arrowhead shows exported PfGARP outside of the parasitophorous vacuole consistent with the presence of a PEXEL motif. (B) PfGARP colocalized with Band 3 but not MSP1, a merozoite surface protein. (C) (Top) Live parasite IF analysis suggesting PfGARP signal is detected on the surface of infected erythrocytes. (Bottom) IF analysis under non-permeabilizing conditions further suggests the surface localization of PfGARP.

Almukadi H, Schwake C, Kaiser M, Mayer G, Schiemer J, Baldwin M, Hegde S, Lu Y, Hanada T, Chishti AH. Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid-rich protein. Blood. 2018 Dec 13. pii:blood-2018-07-865451.