Localization of PfPH2 in free merozoites. A, B IFA showing that PfPH2 does not colocalize with markers of the micronemes: PfAMA1 (secreted on the parasite surface in free merozoites), PfEBA175, and PfEBA140 (A) or of the rhoptry markers PfRON4, PfRAP1, PfRH1, and PfRH5 (B). Scale bar represents 5 lm. Blue: DAPI-stained nucleus. no strong colocalization could be seen between PfPH2 and any of the markers. the PfPH2 signal often seemed to be more apical (Fig EV3Aii and iii and B).
Ibrahimzadeh Z, Mukherjee A, Crochetière MÈ, Sergerie A, Amiar S, Thompson LA, Gagnon D, Gaumond D, Stahelin RV, Dacks JB, Richard D. A pan-apicomplexan phosphoinositide-binding protein acts in malarial microneme exocytosis. EMBO Rep. 2019 May 16. pii: e47102.
Other associated proteins
|PF3D7_0102200||ring-infected erythrocyte surface antigen|
|PF3D7_0402300||reticulocyte binding protein homologue 1 normocyte binding protein 1|
|PF3D7_0424100||reticulocyte binding protein homologue 5|
|PF3D7_0424200||reticulocyte binding protein homologue 4|
|PF3D7_0731500||erythrocyte binding antigen-175|
|PF3D7_1116000||rhoptry neck protein 4|
|PF3D7_1337700||phosphoinositide-binding protein ph2|
|PF3D7_1353600||ER lumen protein retaining receptor|
|PF3D7_1410400||rhoptry-associated protein 1|