PF3D7_1222700 glideosome-associated protein 45

PfCINCH (P. falciparum coordinator of nascent cell detachment) is a member of the Plasmodium basal complex. a Schematic of inner membrane complex (IMC) and basal complex formation in schizogony. At 42–44 h post invasion, basal complex formation is nucleated near the apical ends of forming daughter cells at the basal end of the IMC. As segmentation progresses from ~44–46 h, the basal complex resides at the leading edge of membrane formation, while the IMC stretches from the basal complex to the apical pole of the cell. When segmentation is complete at ~46–48 h, the IMC extends from the apical to the basal pole of the cell, while the basal complex resides exclusively at the posterior end of the merozoite. b Confocal microscopy of PfCINCH and PfGAP45 (IMC marker) throughout segmentation. PfCINCH forms small rings at the apical end of the nascent daughter cell prior to the final synchronous round of cell division (b). As segmentation progresses, PfCINCH tracks along the outer rim of the daughter cell, at the leading edge of the IMC, defined by positive staining for PfGAP45. Finally, when segmentation is complete, PfCINCH resides exclusively at the basal end of merozoites (b). This expression pattern mirrors that of the known Plasmodium basal complex proteins, PfBTP1 and PfMORN1.

Rudlaff RM, Kraemer S, Streva VA, Dvorin JD. An essential contractile ring protein controls cell division in Plasmodium falciparum. Nat Commun. 2019 10(1):2181.

Other associated proteins

PFID Formal Annotation
PF3D7_0407800 coordinator of nascent cell detachment CINCH
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