PVM nutrient-permeable channel but not protein export is impaired in ΔEXP1 parasites. (A) IFA images of control and ΔEXP1 parasites (rapalog) probed with α-HA (EXP1*-HA) and α-KAHRP. Graph to the right shows quantification of export (n = 20 cells). ΔEXP1 parasites showed no defect in the export of knob-associated histidine-rich protein (KAHRP).
Mesén-Ramírez P, Bergmann B, Tran TT, Garten M, Stäcker J, Naranjo-Prado I, Höhn K, Zimmerberg J, Spielmann T. EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites. PLoS Biol. 2019 17(9):e3000473