PF3D7_0934800 cAMP-dependent protein kinase catalytic subunit

Conditional regulation of PfPKAc. Widefield imaging of NF54 PfPKAc:loxP schizonts labeled with anti-GAP45, anti-HA, and DAPI. PfPKAc-HA shows partial peripheral and cytoplasmic localization. Scale bars represent 2.5 mm. Immunofluorescence (IF) analysis of control PfPKAc-HA parasites showed a cytoplasmic and slightly peripheral membrane localization of the PfPKAc-HA fusion protein around the developing merozoites compared to PfGAP45. rapamycin led to a specific loss of PfPKAc-HA signal without affecting the localization of PfGAP45.

Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ. Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes. MBio. 2019 10(5).

Other associated proteins

PFID Formal Annotation
PF3D7_1222700 glideosome-associated protein 45